منابع مشابه
Genetic disease and amyloid.
Amyloid results from the deposition, principally in connective tissue, of polymers that are for the most part incompletely digested precursor proteins. In man the resulting deposits are very resistant to resorption or digestion: their relentless accumulation often causes death by interfering with the function of vital organs such as the kidneys, heart, and gut. There are three definitive method...
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Alzheimer's desease is the most common age-related neurodegenerative disorder, and cognitive problems such as defects in learning and memory are of its symptoms. Among the factors involved in the pathogenesis of the disease are biochemical disorders in protein production, oxidative stress, decreased acetylcholine secretion and inflammation of the brain tissue. Extra-neuronal accumulation ...
متن کاملAmyloid Hypothesis and Alzheimer's Disease
This chapter reviews the major hypotheses in Alzheimer’s disease (AD) research with the focus on amyloid hypothsis. Since amyloid hypothesis of AD pathology was proposed, extracellular amyloid β (Aβ) toxicity and its role of inducing synaptic plasticity and memory function has been studying intensively. Accumulating evidence indicates that Aβ also exists inside the neurons in AD. Intracellular ...
متن کاملUnderstanding amyloid and Alzheimer's disease
Grey matter: A composite image showing a healthy brain (right) and one with Alzheimer’s dis‐ ease (left) gives an impression of the changes associated with the disease. However, even the most sophisticated brain imaging methods available today cannot give a completely reliable diagnosis of Alzheimer’s disease. (Image: Sciencephotolibrary.) Just over a century ago, on the third of October 1910, ...
متن کاملRheumatoid arthritis and amyloid disease.
Introduction The greater part of the literature on the occurrence of amyloidosis in rheumatoid arthritis and in Still's disease comes from the Western Hemisphere. Since the recent publication in this country of such a case by Yeoman and Wilson (1947) the interest of rheumatologists on this side of the Atlantic has been awakened and a watch has been kept for further cases. Over 200 cases of rheu...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1978
ISSN: 0021-9746
DOI: 10.1136/jcp.31.suppl_12.128